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Michigan Nukes Expensive Cancer-Radiation Sites

May 5th, 2008 @ 1:00 am

7 Comments

Tags: Hospital, Center, Healthcare, David P. Hamilton

WWII ration stampsWhen a Michigan commission recently voted to deny several hospitals the right to build expensive “proton-beam therapy” sites for cancer treatment, it took a major step into the brave new world of explicit healthcare rationing.

The rationale behind the decision was fairly straightforward. Four hospitals had each planned to build a new proton-beam treatment facility, which provides a new type of radiation therapy for cancer using an enormous particle accelerator, at a cost of more than $100 million apiece. Instead, however, the state’s Certificate of Need Commission, which sets hospital-construction standards, said it would only allow one center to proceed, and ordered the state’s largest hospitals to work together to build and run it.

Proton-beam treatment may be more accurate — and thus somewhat safer and more effective — than traditional X-ray radiation therapy, although that advantage hasn’t really been proven to anyone’s satisfaction. Because the technology is shiny and new, however, hospitals see proton-beam centers as prestigious facilities that can attract new patients and doctors, potentially giving them an edge over their rivals. The centers are also likely to be quite lucrative, as high-end cancer care tends to be reimbursed by insurers at fairly high rates.

The problem for the state, of course, is that four new proton-beam centers would rack up huge medical costs. (All would likely operate at close to capacity, due to the way boosting the supply of new medical technologies tends to create fresh demand for their use.) “The costs of multiple centers, each having the most expensive medical equipment yet developed, would be tremendous,” the state commission said.

Because of their expense, proton-beam centers appear to be breaking down the reluctance of many states to explicitly ration medical care by interfering with hospital-construction plans. A similar commission in Illinois, for instance, said last month that it may deny one of two proton-beam facilities planned for the Chicago suburbs.

Of course, healthcare is already rationed in the U.S. — it’s just that it’s usually done so covertly and haphazardly via insurance status and the ability to pay large up-front hospital bills or significant coinsurance for expensive drugs. The main reason, of course, is that overt rationing is never very popular. States that decide to limit the availability of new but unproven treatments could very easily face a political backlash. Such policies can also cross powerful business interests such as hospitals and their partners, who can mobilize legal and political counterattacks.

Ugly as it is, however, explicit rationing is an entirely understandable response to escalating medical costs and hospitals that have no incentive not to build out expensive but duplicative facilities in their zero-sum pursuit of patients and profits. For that very reason, though, rationing is pretty likely to fail as a cost-control measure — it makes no one happy, and simply requires the expenditure of too much political capital in order to ward off intangible future costs.

Image by Flickr user freeparking, CC 2.0

A 14-year veteran of the Wall Street Journal, David P. Hamilton is BNET's Industries editor. Prior to coming to BNET, David founded the LifeScience section of VentureBeat, a news site for the innovation and venture business.

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  • BeckyTech05/06/08 Report as spam
    1

    Proton Beam Therapy

    "Because the technology is shiny and new..."

    No, it is not. Loma Linda University Medical Center has been treating many types of cancer patients since 1990.

    "Proton-beam treatment may be more accurate — and thus somewhat safer and more effective — than traditional X-ray radiation therapy, although that advantage hasn’t really been proven to anyone’s satisfaction."

    Again, this is an inaccurate statement. Unlike conventional radiation, proton beam therapy does very little damage on the way in, releases its energy at the desired site (the "Bragg Peak") and does no damage on the way out. The site and surrounding tissue can be targeted to within millimeters.

    In addition, the patient suffers little to no effects, very unlike conventional radiation.

    Yes, facilities are expensive to build, but because there is virtually no collateral damage, there is no need for expensive follow-up and after care.

    In addition, there are months-long waiting lists at the few existing proton centers in the U.S.

    It's interesting that the people who write so negatively about proton therapy have usually talked to traditional radiation oncologists who are deeply vested in IMRT.

    My interest? A close friend of mine was treated for prostate cancer by proton therapy and suffers none of the usual consequences of other prostate treatments.

    Mr. Hamilton, do yourself and your readers a favor and talk to doctors and patients who have been treated by proton. And please, get your facts straight.

    Thank you.

  • WELPLEON05/07/08 Report as spam
    2

    RE: Michigan Nukes Expensive Cancer-Radiation Sites

    The law of supply and demand will effectively lock out those without the means. Is the Commission looking out for patients or the insurance companies?

  • David P Hamilton05/07/08 Report as spam
    3

    Proton therapy

    First, thanks for your comments.

    @BeckyTech: You're certainly correct that proton therapy itself isn't new -- it actually dates back to 1954. Until fairly recently, though, the main proton-beam centers were all co-located at particle-physics facilities. Loma Linda claims to have been the first hospital-based proton facility in the world, and was the only one in the U.S. until 2003.

    So what I meant to say is that the technology is new in the sense of only recently being more widely available. Sorry for the inaccuracy.

    As for its advantages -- sure, depth-specified delivery of the radiation dose has any number of theoretical advantages. My point is that proton therapy has never been subjected to a randomized, controlled trial against radiation, so its benefits are largely anecdotal. Of course proponents of the technology are going to argue that theoretical advantages and case-study experience should end the discussion. But proponents of new technologies (or drugs, or devices, or surgical procedures) always argue that. This is why randomized trials exist -- to prove that the benefits actually exist when you control for extraneous variables. That hasn't happened yet with proton therapy.

    IMRT, by the way, is getting better all the time, although it obviously can't ever eliminate the risks of off-target radiation doses. All the more reason to run the trial and see what the advantages of proton treatment look like in comparable patient populations.

    @WELPLEON, I doubt supply and demand will have a huge impact on who's treated, since most hospitals don't schedule patients based on their ability to pay. (Medical ethics still hold sway in this realm, so far as I know.) I suspect the Michigan commission is mostly looking out for state finances, particularly the state's share of Medicaid, which would presumably be on the hook to cover proton treatment for indigent patients.

  • BeckyTech05/08/08 Report as spam
    4

    Proton vs. IMRT

    Actually, I think the difference between "the technology is shiny and new" and "new in the sense of only recently being more widely available" falls more into the category of misleading than inaccuracy.

    Honestly, David, would YOU participate in a trial of IMRT vs. proton? Who would when the differences were explained: Oh, by the way, with IMRT you might experience a few problems like incontinence, urinary retention requiring a catheter, pain, impotence, strictures of the urethra, and possibly permanent damage to your rectum. OR, you could be put in a trial where you would get proton and after your treatment you could go out and play golf, shop, etc. You'll never need diapers or experience ED from the treatment. And by the way, since you get a higher dose of radiation with proton, the chances of recurrence are much less than with IMRT.

    I just bet they would get a lot of takers for THAT trial.

    When the founder of the University of Florida's surgical oncology
    program and former director of the UF Shands Cancer Center, Ted Copeland, was diagnosed with prostate cancer, guess which treatment HE chose?

  • David P Hamilton05/08/08 Report as spam
    5

    Re: Proton vs. IMRT

    @BeckyTech: Well, "misleading" may be in the eye of the beholder, but I had no intention of giving anyone a false impression. The fact is that proton therapy is suddenly hot in the medical-center world, partly due to prostate-cancer patient activism and partly because it's become more affordable for individual medical centers to consider building out. "Shiny and new" is an evocative phrase, not a term of art, and proton therapy is definitely both, at least in the sense that it's become a major "must have" for medical centers who undoubtedly see it as a potential cash cow.

    In any case, I've already apologized for any misunderstandings, so I don't have a lot more to say on that front.

    As for a trial of proton vs. IMRT -- maybe you're right. On the other hand, if it offered to cover the expenses of participating patients, I bet you wouldn't have much trouble fully enrolling it. PT certainly sounds great, but so have lots of medical technologies whose purported advantages vanished once researchers looked them in a controlled and randomized fashion. Case in point: High-dose chemo and marrow transplant for breast cancer, which went through a similar boom in the 1990s before trials finally showed that it didn't help women live longer and subjected them to horrible side effects to boot.

    Clinical trials certainly aren't infallible, but they're the best tool we've got for separating medical reality from medical hype. "Data" isn't the plural of "anecdote" (or of "clinical case study," for that matter).

    Plus, only once you have the evidence in hand can you get down to the brass tacks of figuring cost-benefit ratios -- which are only going to become more important as overall healthcare costs escalate.

  • BeckyTech05/09/08 Report as spam
    6

    Clinical Trials

    I don't see how a clinical trial is really applicable in this case. It's not like medication vs. a placebo, they ARE going to know what type of treatment they're receiving from the start. I mean it all boils down to following the patients' treatment closely and gathering data as you go along, as well as a significant follow-up period. Why not put researchers in each type of facility and follow a broad number of patients as they go through their chosen treatment? What would the difference be in the long run as far as the results of the study?

  • David P Hamilton05/09/08 Report as spam
    7

    Re: Clinical Trials

    @BeckyTech: Short of a clinical trial, you have no way to know if subtle biases are affecting your interpretation of which patients are actually doing better. PT proponents, for instance, might be selecting a particular type of patient who tends to to particularly well under PT by comparison with "historical" experience of all cancer patients eligible for radiation treatment. There's nothing necessarily untoward about this -- lots of biases are unconscious. That's why it's important to do trials that minimize them (they're almost impossible to eliminate outright).

    And you're absolutely correct that there's no way to double-blind such a trial (or even to single-blind it, as patients could easily figure out which facility they're being assigned to). So you'd do the next-best thing, which would be to control the trial by setting specific volunteer criteria (cancer advanced to such-and-such a stage, people with other complications such as heart disease or whatever disallowed, and so forth) and then randomize it by flipping a coin to assign each patient to one arm of the trial in order to eliminate the possibility of investigator bias in patient selection. You'd probably also want to "blind" the X-rays or MRIs used to assess tumor response, so that radiologists wouldn't know if the scan they're looking at comes from a PT treatment or IMRT. Ideally, the physicians monitoring side effects also wouldn't know which treatment a patient got, although that might not be practical.

    In other words, it's eminently doable. The main problem is that it would be awfully expensive -- PT isn't cheap -- and would take a while. But getting a definitive answer everyone could rally around would be worth it, IMO.

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David P. Hamilton

David P. Hamilton, a 14-year veteran of the Wall Street Journal, is a freelance business and medical writer in San Francisco. He most recently founded the LifeScience section of VentureBeat, a news site for innovation and venture business. Previously, David covered biotechnology, the Internet, and computing and served as a Tokyo foreign correspondent for the Journal. He is a two-time winner of the Overseas Press Club award and spent several years as a reporter at... more »

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