About Pharma Industry

BNET Pharma provides daily industry trends and news coverage with insights for managers and executives about major manufacturers of pharmaceuticals and medicine. In addition to detailed drug company profiles, we bring you industry analysis on new partnerships, drug patents and products, cost management, investments, pharmaceutical related lawsuits, and a host of other important business issues.

"Pfizer Math" Showed Lyrica Superiority Even Though Studies Never Said That, Rep Claims

By Jim Edwards | Sep 15, 2009

Pfizer used “Pfizer Math” to persuade doctors that Lyrica was superior to two anti-seizure drugs, Neurontin and Keppra, when no comparable studies had been done — and Lyrica was not approved to treat seizures — according to two former pharmaceutical sales reps.

According to the suit (settled as part of the $2.3 billion Bextra deal):

Pfizer representatives were trained to, and did, use what they called internally “Pfizer Math” to intentionally create the false impression that there had been head-to-head comparisons between Keppra and Lyrica showing Lyrica superiority when there were no such studies.

Pfizer denied the allegations:

Pfizer denies all federal, state and qui tam allegations, with two exceptions. We acknowledge certain improper actions related to the past promotion of Bextra and Zyvox. Beyond those two exceptions we deny all federal and state and qui tam claims.

In terms of Neurontin, Farber alleges reps were given two studies, “Dworkin” and “Rowbotham,” to tell doctors about:

(Click to enlarge)

There are no adequate, controlled, head-to-head studies of Lyrica vs. Neurontin, Farber claims. In 2006, Pfizer withdrew the sales materials in which the two studies were compared, the suit claims.

Lyrica was given a histrionic launch in 2005, according to the suit:

The suit was brought by David Farber, an Iowa City, Iowa, rep, and Casey Schildhauer of Los Angeles. The law firms representing them were Blank Rome of Washington, D.C., and Robins, Kaplan, Miller & Ciresi of Boston. Farber and Schildhauer both claim they were let go by Pfizer after they complained about the way Lyrica and other drugs were promoted.

Jim Edwards, a former managing editor of Adweek, has covered drug marketing at Brandweek for four years, and is a former Knight-Bagehot fellow at Columbia University's business and journalism schools. Follow him on Twitter or send him an email.

BNET User Analysis

Web Buzz:
  • What Docs Didn't Know About Pfizer's Neurontin

    BNET Pharma - 120 days 7 hours 5 minutes ago

    Here’s a depressing exchange in the litigation on Pfizer’s anti-seizure med, Neurontin. It’s between the doctor of Susan Bulger, who killed herself after taking the pill. Her family claims Pfizer knew the drug caused suicidal thoughts in some people but sat on information: Last year, Bulger’s doctor, Dino Crognale testified in a...

  • Trial data on Neurontin may have been manipulated

    FierceHealthcare - 9 days 6 hours 50 minutes ago

    A new paper published in the New England Journal of Medicine has accused drugmaker Pfizer of manipulating clinical data on trials of anti-seizure drug Neurontin (gabapentin). The accusations stem from a look at internal Pfizer documents exposed by a lawsuit in which author Kay Dickersin was an expert witness. She'd been asked to testify in a...

  • Pfizer - Neurontin: David Franklin and the private eye

    PharmaGossip - 103 days 11 hours 57 minutes ago

    Did Pfizer, the world's largest pharmaceutical company, cross the line on the eve of last month's crucial test trial involving its controversial anti-seizure medication Neurontin?Two weeks after the trial abruptly ended with the plaintiffs agreeing to dismiss their case with prejudice, questions linger about why Pfizer sent a former CIA agent...

  • Pfizer's recidivism - Martha Rosenberg writes

    PharmaGossip - 46 days 20 hours 33 minutes ago

    It's Deja Vu All Over Again for Pfizer Pfizer's $2.3 billion settlement announced last month by the US Department of Justice, for fraudulent marketing of Bextra, Geodon, Lyrica and Zyvox inducts the world's biggest drug maker into the pharma Three-Peat Hall of Fame. It's only been five years since Pfizer agreed to pay $430 million for seizure...

  • Abbott profit hurt by dollar and generics

    Reuters - 129 days 11 hours 32 minutes ago

    NEW YORK (Reuters) - Abbott Laboratories Inc's (ABT.N) second-quarter earnings fell 2.6 percent, with generic competition for its Depakote anti-seizure drug overshadowing strong sales of its Humira arthritis drug and its Xience heart stent. Shares of the suburban Chicago drugmaker fell 1.6 percent as its global revenue came in slightly below...

Links from the Web Buzz:
 

BNET TalkbackShare your ideas and expertise on this topic

Please add your comment:

  1. You are currently: a Guest |
  2.  

Basic HTML tags that work in comments are: bold (<b></b>), italic (<i></i>), underline (<u></u>), and hyperlink (<a href></a)

advertisement
advertisement
  • Click Here
  • Click Here
  • Click Here
advertisement
Click Here